Andie P. MS LifeLines Ambassador,
living with relapsing MS

MS LifeLines is a support service that’s here to help you start and stay on a relapsing MS treatment. If you’d like to talk to someone—even before you decide on a multiple sclerosis therapy—MS LifeLines is here for you. Just call 1-877-447-3243 anytime.

You can learn more about MS LifeLines at 1-on-1 Support.

MS LifeLines support staff is here to help

MS LifeLines Nurses

You're not alone. Seven days a week you can reach a trained nurse at our MS LifeLines call center for expert advice on injecting, managing certain side effects, and more. We can also send a nurse to your home to teach you proper injection technique. All of our call center nurses are MS certified.

Call us if:

  • You have any questions about injections
  • You have any questions about treating with Rebif® (interferon beta-1a)
  • You would like a home visit for injection training or retraining

Patient and care partner ambassadors

We’re people living with relapsing MS and the care partners who support them. We know how sometimes it can feel like you’re taking on multiple sclerosis alone. That’s why you can call and arrange to speak with one of us directly.

Financial Support Specialists

Financial Support Specialists can help you work through insurance questions and determine whether you are eligible for a financial assistance program. Even if you don't have insurance, MS LifeLines may be able to help.

Taking the first step

As soon as MS LifeLines learns you have been prescribed Rebif by your doctor, with your consent, an MS LifeLines Nurse Support Specialist will contact you. He or she will:

  • Schedule a field nurse visit to your home so you can receive personalized, 1-on-1 injection training and other therapy support
  • Ship you a Rebif Welcome Kit, which provides information and support to help you start and stay on Rebif as prescribed
  • Connect you to a Financial Support Specialist, who can help you find affordable access to Rebif or navigate your healthcare insurance to help you get the best available coverage for Rebif
  • Answer your questions about living with relapsing MS and taking Rebif therapy

Meet Joanne, an MS LifeLines Nurse

An MS LifeLines Nurse may be one of the first people you meet when starting Rebif. They're here to help you, from walking you through your first injection to answering any questions you may have while on treatment.

Watch “4 Ways Our Nurses Can Help”

Jeanette’s story: Making a connection

Debbie’s Story: Grateful for the help

“We really, truly appreciate the hard work the nurses do to help us with Rebif.”

I struggled with therapies in the beginning because I didn’t feel confident about injecting myself.

My first injection training was amazing. The MS LifeLines Nurse came out and we had a connection from the very beginning. I was surprised that she could help me with overall support, not just administering my shot correctly. She really cared about me as a person.

She listened to my life story, then she went through the whole process to make sure I’m rotating my injection-site areas and properly cleansing the area. It’s just to make sure that I’m on course to administer my shots correctly three days a week, at least 48 hours apart. If I have questions, she’ll come back again.

Before she left, she gave me her card and told me to call anytime. I loved that she goes that extra step. She’ll contact me just to check up on me and make sure everything is going okay, or I will contact her. She does so much for us, the MS patients. I will send her a text message just to say, “Here’s a big cyber hug.”

Jeanette A.Single mother, MS LifeLines Ambassador, living with relapsing MS

This story reflects the personal experience of one person. Results and experiences vary from patient to patient.

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Important Safety Information and Indication

Important Safety Information


Before beginning treatment, you should discuss the potential benefits and risks associated with Rebif with your healthcare provider.

Rebif can cause serious side effects. Tell your healthcare provider right away if you have any of the symptoms listed below while taking Rebif.

  • Behavioral health problems, including depression and suicidal thoughts. You may have mood problems including depression (feeling hopeless or feeling bad about yourself), and thoughts of hurting yourself or suicide
  • Liver problems or worsening of liver problems, including liver failure. Symptoms may include nausea, loss of appetite, tiredness, dark colored urine and pale stools, yellowing of your skin or the white part of your eye, bleeding more easily than normal, confusion, and sleepiness. During your treatment with Rebif you will need to see your healthcare provider regularly and have regular blood tests to check for side effects
  • Serious allergic and skin reactions. Symptoms may include itching, swelling of your face, eyes, lips, tongue or throat, trouble breathing, anxiousness, feeling faint, skin rash, hives, sores in your mouth, or skin blisters and peels
  • Injection site problems. Symptoms at the injection site may include redness, pain, swelling, color changes (blue or black), and drainage of fluid
  • Blood problems. Rebif can affect your bone marrow and cause low red and white blood cell and platelet counts. In some people, these blood cell counts may fall to dangerously low levels. If your blood cell counts become very low, you can get infections and problems with bleeding and bruising. Your healthcare provider may ask you to have regular blood tests to check for blood problems
  • Seizures. Some people have had seizures while taking Rebif

Rebif will not cure your MS but may decrease the number of flare-ups of the disease and slow the occurrence of some of the physical disability that is common in people with MS.

Do not take Rebif if you are allergic to interferon beta, human albumin, or any of the ingredients in Rebif.

Before you take Rebif, tell your healthcare provider if you have or have had any of the following conditions:

  • mental illness, including depression and suicidal behavior
  • liver problems, bleeding problems or blood clots, low blood cell counts, seizures (epilepsy), or thyroid problems
  • you drink alcohol
  • you are pregnant or plan to become pregnant. It is not known if Rebif will harm your unborn baby. Tell your healthcare provider if you become pregnant during your treatment with Rebif
  • you are breastfeeding or plan to breastfeed. It is not known if Rebif passes into your breast milk. You and your healthcare provider should decide if you will use Rebif or breastfeed. You should not do both

Tell your healthcare provider about all medicines you take, including prescription and over-the-counter medicines, vitamins and herbal supplements.

The most common side effects of Rebif include:

  • flu-like symptoms. You may have flu-like symptoms when you first start taking Rebif. You may be able to manage these flu-like symptoms by taking over-the-counter pain and fever reducers. For many people, these symptoms lessen or go away over time. Symptoms may include muscle aches, fever, tiredness, and chills
  • stomach pain
  • change in liver blood tests

Tell your healthcare provider if you have any side effect that bothers you or that does not go away.

These are not all the possible side effects of Rebif. For more information, ask your healthcare provider or pharmacist.

Call your doctor for medical advice about side effects.

Refer to the Instructions for Use that comes with Rebif® Rebidose® (interferon beta-1a) autoinjector.


Rebif® (interferon beta-1a) is used to treat relapsing forms of MS to decrease the frequency of relapses and delay the occurrence of some of the physical disability that is common in people with MS.