Administration

3 options to consider

Rebif Rebidose is one way to take Rebif. The portable, preassembled, prefilled single-use autoinjector provides you and your doctor the flexibility of 2 dosing options—44 mcg and 22 mcg.

You can also choose a prefilled syringe with or without the reusable Rebiject II® autoinjector.

  • Rebif is shipped to you in prefilled, preassembled, ready-to-use syringes, so no premixing or assembly is required.
  • With Rebiject II and Rebif Rebidose, the needle stays covered before and after injection process.
  • Rebif may cause redness, pain, or swelling at the place where an injection was given. Some patients have developed skin infections or areas of severe skin damage (necrosis) requiring treatment by a health care provider. If one of your injection sites becomes swollen and painful or the area looks infected and it doesn't heal within a few days, you should call your health care provider. For more information, please see medication guide.
  • 3-times-weekly dosing schedule allows for injection-free weekends. Injections should be at least 48 hours apart. Rebif treatment schedule chart
  • Rebif is injected under the skin; Avonex® (interferon beta-1a) is injected into the muscle.
  • Rebif should be refrigerated between 36°F and 46°F (2°C to 8°C). Do not freeze. If refrigeration is not available, Rebif can be stored between 26°F and 77°F (2°C to 25°C) for up to 30 days, away from heat and light.
  • If you're just starting on Rebif therapy, the Rebif Titration Pack includes premeasured, prefilled dosing. No mixing or measuring required.
  • Rebif has two approved doses—22 mcg and 44 mcg. You and your health care provider can decide which dose is right for you.

Learn more about injection options and support to get you started with Rebif.

Ron B.
MS LifeLines Ambassador, living with relapsing MS

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