Proven effective
Rebif® (interferon beta-1a) is the only self-injected therapy proven to achieve all 3 key treatment goals in relapsing MS
This was shown in the 2-year PRISMS§ study that included 560 people to see how they responded to either dose of Rebif, Rebif 22 mcg or Rebif 44 mcg, versus placebo. Doses were given under the skin 3 times per week, at least 48 hours apart.
‡New or enlarging lesions detected with PD/T2-weighted MRI.
*The exact correlation between MRI findings and the current or future clinical status of patients, including disability progression, is unknown.
Learn more about the PRISMS study.
Please see important safety information below and the Rebif Medication Guide and Prescribing Information in the top right corner of this website, and speak with your doctor for more information.
Rebif is the only relapsing MS treatment proven to work better than another in a class I clinical trial
This was shown in the EVIDENCE** study, which was a head-to-head trial that compared Rebif (interferon beta-1a) with Avonex® (interferon beta-1a) over an average of 64 weeks. Rebif 44 mcg was given to 339 people 3 times per week, at least 48 hours apart just under the skin. Avonex 30 mcg was given to 338 people once per week into the muscle.
‡New or enlarging lesions detected with PD/T2-weighted MRI.
*The exact correlation between MRI findings and the current or future clinical status of patients, including disability progression, is unknown.
Learn more about the EVIDENCE study.
In the EVIDENCE study, those taking Rebif had similar side effects to those taking Avonex
Compared with Avonex, side effects were generally similar with Rebif despite the higher, more frequent dosing of Rebif.
Differences included:
- People taking Avonex had more flu-like symptoms than those taking Rebif.
- People taking Rebif had a greater number of injection-site reactions, elevated liver enzymes, and decreased white blood cell counts.
In addition, the number of people who dropped out of the study because of adverse events was 5% with Rebif and 3% with Avonex.
Injection-site reactions and flu-like symptoms (fever, chills, sweating, muscle aches, and tiredness) are common side effects with Rebif. But there are things you can do to help manage them.
Your health care professional can help you monitor and manage side effects or adverse events if they occur.
Related Topics
§Prevention of Relapses and Disability by Interferon beta-1a Subcutaneously in Multiple Sclerosis
**EVidence for Interferon Dose-response: European North American Comparative Efficacy
