A well-established safety profile with 18 YRS' clinical trial and patient experience

Safety profile

Rebif® (interferon beta-1a) has a well-established safety profile, backed by more than 19 years of clinical trial and patient experience

The safety and efficacy of treatment with Rebif beyond 2 years has not been established.

Important safety information

Rebif will not cure multiple sclerosis (MS) but it has been shown to decrease the number of flare-ups and slow the occurrence of some of the physical disability that is common in people with MS. Rebif can cause serious side effects, so before you start taking Rebif, you should talk with your health care provider about the possible benefits of Rebif and its possible side effects to decide if Rebif is right for you.

The most common side effects of Rebif are injection-site reactions, flu-like symptoms, depression, abdominal pain, elevated liver enzymes, and blood abnormalities. Potential serious side effects include liver problems with severe liver injury possible, depression, suicidal ideation, suicide attempts, risk to pregnancy, allergic reactions, and injection-site problems with a chance of infection or severe skin damage.

The MS LifeLines Nurse Network: providing support in MS care

MS LifeLines has a vast team of MS-certified and experienced nurses to answer questions about living with MS and Rebif and provide injection training. With nurses located throughout the US, there is always someone available to talk with you—whether it's on the phone or in person. Call 1-877-447-3243 to speak with a nurse or to schedule an in-home visit.

The MS LifeLines Nurse Network is available to help answer your questions, provide injection training and offer tips that may help with certain side effects.

Call 1-877-447-3243 Monday through Friday 8 AM to 10 PM ET and Saturday and Sunday from 9 AM to 5 PM ET.

Remember to talk to a health care provider if you have any questions or concerns about symptoms or side effects.

Rebif clinical trial safety data

Treating relapsing MS is a commitment—so knowing what you might expect from a treatment regimen is important. You can be confident that the safety profile of Rebif is backed by 19 years of clinical trial and patient experience.

Important safety information

Who should not take Rebif?

If you have any of the following conditions or serious medical problems, you should tell your health care provider before taking Rebif:

  • Depression (a sinking feeling or sadness), anxiety (feeling uneasy or fearful for no reason), or trouble sleeping
  • Liver diseases
  • Problems with your thyroid gland
  • Blood problems such as bleeding or bruising easily and anemia (low red blood cells) or low white blood cells
  • Epilepsy
  • Are planning to become pregnant

If you have questions about Rebif therapy or are uncertain about side effects, you are not alone. MS LifeLines—a network of support and community of people dedicated to helping those with MS—is here for you 24 hours a day, 7 days a week, regardless of whether or not you take Rebif.

Read more about clinical trials and Rebif in the PRISMS and EVIDENCE studies.

Ron B.
MS LifeLines Ambassador, living with relapsing MS

Rebif infokit
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