Rebif® (interferon beta-1a) offers you the option of using a prefilled, preassembled, ready-to-inject syringe for Rebif administration.

You should use the Rebif prefilled syringe only after you have received proper training from a medical professional. Contact MS LifeLines® about scheduling a field nurse to provide injection training to you in the comfort of your home. Call 1-877-44-REBIF (1-877-447-3243) to learn more. You can also watch an injection training video on this webpage for a quick refresher.

  • No premixing or assembly is required for Rebif.
  • No twisting, turning, pulling or adjusting of the syringe is necessary before injection.
  • How to use the Rebif syringe

    1. Pinch the skin around the cleaned injection site to lift it up a bit, and hold the syringe like a pencil or dart.

    2. While still pinching the skin, use a quick, firm motion to insert the needle straight into the skin at about a 90-degree angle.

    3. With the needle inserted, stop pinching the skin and gently, steadily push the plunger all the way down.

    4. Remove the needle and apply gently pressure to the injection site with a dry cotton ball or sterile gauze. Applying a cold compress or ice pack to the injection site after injection may help reduce local skin reactions.

    5. Discard the empty syringe and cap in the syringe disposal container,* and keep a record of the date and injection site in your treatment journal.

      *Regulations for disposal vary. Consult your doctor or pharmacist for regulations in your area.

    6. Check recent injection sites for redness, swelling or tenderness. Contact your health care professional about any skin reaction that does not clear up in a few days. You can also contact an MS LifeLines Nurse Support Specialist, who can give you tips that may help manage these reactions.

    For more information about the Rebif prefilled syringe, call MS LifeLines toll-free at 1-877-44-REBIF (1-877-447-3243) Monday through Friday, 8 AM to 10 PM ET and Saturday and Sunday from 9 AM to 5 PM ET. For complete instructions on the use of the Rebif prefilled syringe, please refer to the instructions that came with it.

    Regulations for needle disposal vary. Consult your physician or pharmacist for the regulations in your area.

    Rebif is used to treat relapsing forms of MS to decrease the frequency of relapses and delay the occurrence of some of the physical disability that is common in people with MS. Rebif is not approved for treatment of chronic progressive MS.

    Please see important safety information below and Rebif Medication Guide and Prescribing Information in the top of this website, and speak with your doctor for more information.

    Betaseron is a registered trademark of Bayer HealthCare Pharmaceuticals Inc.
    Extavia is a registered trademark of Novartis AG.

Marcia J.
MS-Certified Field Nurse, MS LifeLines