Treatment routine

When you start on a disease-modifying drug (DMD), you want to know that it has proven efficacy to treat relapsing multiple sclerosis (MS) and slow the progression of disability. You may also be looking for a therapy with product features designed for flexibility.

Rebif® (interferon beta-1a) offers proven efficacy. It also offers product features that are designed for flexibility.

Taking Rebif three times weekly at least 48 hours apart as prescribed by your doctor means that you can pick the days that work best with your schedule—you can even choose to keep your weekends injection-free.

Injection free weekends

Rebif is administered by a subcutaneous injection just under the skin and currently offers 3 injection options:

  • Rebif® Rebidose® (interferon beta-1a)
    Rebif Rebidose gives you the option of a preassembled, prefilled, single-use autoinjector.
  • Rebiject II®
    The Rebiject II autoinjector is designed to automate the Rebif injection. With the Rebiject II, the needle remains hidden both before and after injecting.
    • Rebiject II is available free of charge for use with your Rebif prefilled syringe through MS LifeLines®. You can call toll-free at 1-877-447-3243 Monday through Friday, 8 AM to 10 PM ET.
  • Rebif prefilled syringe
    Rebif also comes ready-to-use in premeasured, prefilled syringes that already contain medicine and do not require needle assembly. What this means is that you don't have to worry about mixing any solutions before injection. Rebif should be refrigerated. If refrigeration is unavailable, Rebif can be stored at or below room temperature (25°C/77°F) and away from heat and light for up to 30 days.

    If you're just starting on Rebif therapy, there is a Rebif Titration Pack available. Talk to your doctor about what's right for you.

Everyone has a different experience as they start Rebif. For example, you may experience flu-like symptoms or injection-site reactions. If you are experiencing either flu-like symptoms or injection-site reactions, don’t be discouraged—MS LifeLines can give you tips and information that may help you manage these side effects. The nurses at MS LifeLines are required to be MS-certified and are available by calling toll-free 1-877-447-3243 Monday through Friday, 8 AM to 10 PM ET and Saturday and Sunday from 9 AM to 5 PM ET.

Rebif may cause redness, pain or swelling at the place where an injection was given. Some patients have developed skin infections or areas of severe skin damage (necrosis) requiring treatment by a doctor. If one of your injection sites becomes swollen and painful or the area looks infected and it doesn’t heal within a few days, you should call your doctor.

Please see important safety information below and the Rebif Medication Guide and Prescribing Information at the top of this website, and speak with your health care professional for more information. Please see the complete Instructions for Use that come with your Rebif Rebidose autoinjector.

Marcia J.
MS-Certified Field Nurse, MS LifeLines