Treatment routine

When you start on a disease-modifying drug (DMD), you want to know that it has proven efficacy to treat relapsing multiple sclerosis (MS) and delay the progression of disability. You may also be looking for a therapy with product features designed for flexibility and convenience to work with your lifestyle.

Rebif® (interferon beta-1a) offers proven efficacy. It also offers product features that are designed to help make taking Rebif convenient.

Rebif offers flexibility and convenience

Taking Rebif three times weekly at least 48 hours apart as prescribed by your doctor means that you can pick the days that work best with your schedule—you can even choose to keep your weekends injection-free.

Injection free weekends

Rebif is administered by a subcutaneous injection just under the skin and currently offers two injection options:

  • Rebiject II ®
    The Rebiject II auto-injector is designed to make your injections easier than a manual Rebif injection. With the Rebiject II, the needle remains hidden both before and after injecting, which may help some people who don't like to see the needle.
    • Rebiject II is available free of charge through MS LifeLines®. You can call toll-free at 1-877-447-3243 Monday through Friday, 8 AM to 10 PM ET.
  • Rebif prefilled syringe
    Rebif also comes ready-to-use in premeasured, prefilled syringes that already contain medicine and do not require needle assembly. What this means is that you can have a 1-step prep, and you don't have to worry about mixing any solutions before injection. Rebif should be refrigerated. If refrigeration is unavailable, Rebif can be stored at or below room temperature (25°C/77°F) away from heat and light for up to 30 days.

    If you're just starting on Rebif therapy, there is an available Rebif Titration Pack, which includes premeasured, prefilled dosing. Talk to your doctor about what's right for you.

Everyone has a different experience as they start Rebif. For example, you may experience flu-like symptoms or injection-site reactions. If you are experiencing either flu-like symptoms or injection-site reactions, don't be discouraged—MS LifeLines can give you tips and information that may help you manage these side effects. Our MS LifeLines nurses are required to be MS-certified and are available through MS LifeLines; call toll-free 1-877-44-REBIF (1-877-447-3243) Monday through Friday, 8 AM to 10 PM ET and Saturday and Sunday from 9 AM to 5 PM ET.

Please see important safety information below and the Rebif Medication Guide and Prescribing Information in the top right corner of this website, and speak with your health care professional for more information.

Rebif injection training video

Watch this video for tips to improve your injection technique.

This is a test player for the serono test Overhaul

Going somewhere?

Request a Rebif travel kit—compliments of MS LifeLines.

Call toll-free 1-877-447-3243.

Here for you

Call MS LifeLines toll-free at 1-877-447-3243.

Our Reimbursement Specialists and nurse support specialists are available to answer your questions Monday through Friday, 8 AM to 10 PM ET and Saturdays from 9 AM to 5 PM ET.

Nurse support specialists are also available Sundays from 9 AM to 5 PM ET.

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