Rebif three injection options
Jordan S. MS LifeLines Ambassador,
living with relapsing MS
Marcia G. RN, MSCN,
MS LifeLines Nurse

Rebif® (interferon beta-1a) is administered subcutaneously, which means you inject Rebif under the skin. There are 3 options available for injecting Rebif and 2 dosing options—22 mcg and 44 mcg. If you're just starting on Rebif therapy, there is also a Rebif Titration Pack available that can be used to gradually increase your dose. Only prefilled syringes can be used to titrate to a 22 mcg prescribed dose. Talk to your doctor about what's right for you. Rebif should be stored refrigerated between 36°F and 46°F (2°C to 8°C). Do not freeze. If a refrigerator is not available, Rebif may be stored between 36°F and 77°F (2°C to 25°C) for up to 30 days and away from heat and light.

Rebif® Rebidose® (interferon beta-1a)

Rebif Rebidose gives you the option of a preassembled, prefilled, single-use autoinjector. Here, you can learn more about how Rebif Rebidose works and what people said in a user trial as well as brush up on practical issues like traveling with Rebif Rebidose and disposal. For complete instructions, please refer to the Instructions for Use.

Rebiject II® autoinjector

The Rebiject II autoinjector works with the Rebif prefilled syringe and is designed to automate the injection process. You can learn more here about how Rebiject II works, how to use it, and even how you can get Rebiject II free of charge.

Rebif prefilled syringe

Rebif also comes ready to use in preassembled, prefilled syringes that already contain medicine and do not require needle assembly. What this means is that you don't have to worry about mixing any solutions before injection. Learn more about how to use the prefilled syringe, including video instructions.

 
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Important Safety Information and Indication

Important Safety Information

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Before beginning treatment, you should discuss the potential benefits and risks associated with Rebif with your healthcare provider.

Rebif can cause serious side effects. Tell your healthcare provider right away if you have any of the symptoms listed below while taking Rebif.

  • Behavioral health problems, including depression and suicidal thoughts. You may have mood problems including depression (feeling hopeless or feeling bad about yourself), and thoughts of hurting yourself or suicide
  • Liver problems or worsening of liver problems, including liver failure. Symptoms may include nausea, loss of appetite, tiredness, dark colored urine and pale stools, yellowing of your skin or the white part of your eye, bleeding more easily than normal, confusion, and sleepiness. During your treatment with Rebif you will need to see your healthcare provider regularly and have regular blood tests to check for side effects
  • Serious allergic and skin reactions. Symptoms may include itching, swelling of your face, eyes, lips, tongue or throat, trouble breathing, anxiousness, feeling faint, skin rash, hives, sores in your mouth, or skin blisters and peels
  • Injection site problems. Symptoms at the injection site may include redness, pain, swelling, color changes (blue or black), and drainage of fluid
  • Blood problems. Rebif can affect your bone marrow and cause low red and white blood cell and platelet counts. In some people, these blood cell counts may fall to dangerously low levels. If your blood cell counts become very low, you can get infections and problems with bleeding and bruising. Your healthcare provider may ask you to have regular blood tests to check for blood problems
  • Seizures. Some people have had seizures while taking Rebif

Rebif will not cure your MS but may decrease the number of flare-ups of the disease and slow the occurrence of some of the physical disability that is common in people with MS.

Do not take Rebif if you are allergic to interferon beta, human albumin, or any of the ingredients in Rebif.

Before you take Rebif, tell your healthcare provider if you have or have had any of the following conditions:

  • mental illness, including depression and suicidal behavior
  • liver problems, bleeding problems or blood clots, low blood cell counts, seizures (epilepsy), or thyroid problems
  • you drink alcohol
  • you are pregnant or plan to become pregnant. It is not known if Rebif will harm your unborn baby. Tell your healthcare provider if you become pregnant during your treatment with Rebif
  • you are breastfeeding or plan to breastfeed. It is not known if Rebif passes into your breast milk. You and your healthcare provider should decide if you will use Rebif or breastfeed. You should not do both

Tell your healthcare provider about all medicines you take, including prescription and over-the-counter medicines, vitamins and herbal supplements.

The most common side effects of Rebif include:

  • flu-like symptoms. You may have flu-like symptoms when you first start taking Rebif. You may be able to manage these flu-like symptoms by taking over-the-counter pain and fever reducers. For many people, these symptoms lessen or go away over time. Symptoms may include muscle aches, fever, tiredness, and chills
  • stomach pain
  • change in liver blood tests

Tell your healthcare provider if you have any side effect that bothers you or that does not go away.

These are not all the possible side effects of Rebif. For more information, ask your healthcare provider or pharmacist.

Call your doctor for medical advice about side effects.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Refer to the Instructions for Use that comes with the Rebif® Rebidose® (interferon beta-1a) autoinjector.

Indication

Rebif is used to treat relapsing forms of MS to decrease the frequency of relapses and delay the occurrence of some of the physical disability that is common in people with MS.