3 treatment goals
Nicole B. MS LifeLines Ambassador, living with relapsing MS

Rebif® (interferon beta-1a) is proven to meet 3 key treatment goals in relapsing MS.

Slowed disability progression Reduced relapse rate Reduced active brain lesions on studied MRI measures*†
Yes Yes Yes
Slowed disability progression Yes
Reduced relapse rate Yes
Reduced active brain lesions on studied MRI measures*† Yes

This was shown in a large placebo-controlled study of Rebif for relapsing MS called PRISMS. "Placebo-controlled" means that some people in the study received a placebo containing no medicine, while others received Rebif. This is a very common way to study the effectiveness of drugs.

The study included a range of disability in relapsing MS based on their Expanded Disability Status Scale (EDSS) scores. EDSS is used in clinical studies to rate the amount of disability a person has over time on a scale from 0 (least) to 10 (maximum). People in the PRISMS study ranged from 0 to 5.0 on the scale.

The exact correlation between MRI findings and the current or future clinical status of patients, including disability progression, is unknown.

Prevention of Relapses and Disability by Interferon β-1a Subcutaneously in Multiple Sclerosis.

Study results showed Rebif was effective for people with relapsing MS with a range of disability.

2 year prism study chart 2 year prism study chart

The PRISMS study also showed only 26% of people taking Rebif 44 mcg had disability progression§—as opposed to 37% of those taking a placebo. The time to progression of disability, which is the permanent worsening of your neurologic examination over time, was also nearly doubled versus placebo (21.3 months vs 11.9 months).

In the PRISMS study, 3% of those taking Rebif 22 mcg and 5% taking Rebif 44 mcg stopped taking Rebif because of adverse events.

It's important to inform your healthcare provider of any side effects you experience. There may be things you can do to help manage them.

Please see Important Safety Information below and the Rebif Medication Guide and Prescribing Information at the top of this website, and speak with your healthcare provider for more information.

* New or enlarging lesions detected with PD/T2-weighted MRI.
Refers to new lesions and total lesion burden or area as defined in the AAN and MS Council guidelines.
§ Progression of disability was defined as an increase of at least 1 point in the EDSS that was sustained for at least 3 months.
" The central or typical value in a set of data.
From a subgroup of 134 patients in the PRISMS study who received 11 consecutive monthly PD/T2 and gadolinium-enhanced/T1-weighted (Gd-T1) MRI scans beginning 1 month before treatment initiation.
# A value in an ordered set that has an equal number of values higher and lower.
** Based on comparisons from rank-based ANOVA.

Nicole's story:
Looking at the options

"I needed to feel
like
my doctor
and I could
do
something to treat
my relapsing MS."

My diagnosis was difficult on my entire family, especially my children. I knew our lives would be different, but I told them I was going to work with my neurologist to learn how we could treat my relapsing MS.

So the doctor and I talked about treatment options, and she thought Rebif was a good choice for me. She explained the risks, side effects, and benefits of Rebif and said that some evidence from clinical trials has shown that Rebif helps reduce the frequency of relapses and could help slow disability progression associated with relapsing multiple sclerosis.

She also told me that Rebif had been shown to reduce the development of certain brain lesions that you can see on MRIs. What that might mean about my symptoms or how much disability I might have in the future can't be predicted. But my MRI results showed that I had multiple lesions on my brain at the time, so it really got my attention.

And though I realized that there is no cure for MS, I felt ready to start treatment. I needed to feel like my doctor and I could do something to treat my relapsing MS. We talked it over and that is how I decided on Rebif.

Nicole B. Avid fisher and mom, MS LifeLines Ambassador, living with relapsing MS

This story reflects the personal experience of one person. Results and experiences vary from patient to patient.

Talk to someone who understands
living with MS

Talk to someone like Nicole who understands relapsing MS, through the Peer Connection Program. Call 1-866-783-5189.

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Next: Safety Profile
Important Safety Information and Indication

Important Safety Information

7.07

Before beginning treatment, you should discuss the potential benefits and risks associated with Rebif with your healthcare provider.

Rebif can cause serious side effects. Tell your healthcare provider right away if you have any of the symptoms listed below while taking Rebif.

  • Behavioral health problems, including depression and suicidal thoughts. You may have mood problems including depression (feeling hopeless or feeling bad about yourself), and thoughts of hurting yourself or suicide
  • Liver problems or worsening of liver problems, including liver failure. Symptoms may include nausea, loss of appetite, tiredness, dark colored urine and pale stools, yellowing of your skin or the white part of your eye, bleeding more easily than normal, confusion, and sleepiness. During your treatment with Rebif you will need to see your healthcare provider regularly and have regular blood tests to check for side effects
  • Serious allergic and skin reactions. Symptoms may include itching, swelling of your face, eyes, lips, tongue or throat, trouble breathing, anxiousness, feeling faint, skin rash, hives, sores in your mouth, or skin blisters and peels
  • Injection site problems. Symptoms at the injection site may include redness, pain, swelling, color changes (blue or black), and drainage of fluid
  • Blood problems. Rebif can affect your bone marrow and cause low red and white blood cell and platelet counts. In some people, these blood cell counts may fall to dangerously low levels. If your blood cell counts become very low, you can get infections and problems with bleeding and bruising. Your healthcare provider may ask you to have regular blood tests to check for blood problems
  • Seizures. Some people have had seizures while taking Rebif

Rebif will not cure your MS but may decrease the number of flare-ups of the disease and slow the occurrence of some of the physical disability that is common in people with MS.

Do not take Rebif if you are allergic to interferon beta, human albumin, or any of the ingredients in Rebif.

Before you take Rebif, tell your healthcare provider if you have or have had any of the following conditions:

  • mental illness, including depression and suicidal behavior
  • liver problems, bleeding problems or blood clots, low blood cell counts, seizures (epilepsy), or thyroid problems
  • you drink alcohol
  • you are pregnant or plan to become pregnant. It is not known if Rebif will harm your unborn baby. Tell your healthcare provider if you become pregnant during your treatment with Rebif
  • you are breastfeeding or plan to breastfeed. It is not known if Rebif passes into your breast milk. You and your healthcare provider should decide if you will use Rebif or breastfeed. You should not do both

Tell your healthcare provider about all medicines you take, including prescription and over-the-counter medicines, vitamins and herbal supplements.

The most common side effects of Rebif include:

  • flu-like symptoms. You may have flu-like symptoms when you first start taking Rebif. You may be able to manage these flu-like symptoms by taking over-the-counter pain and fever reducers. For many people, these symptoms lessen or go away over time. Symptoms may include muscle aches, fever, tiredness, and chills
  • stomach pain
  • change in liver blood tests

Tell your healthcare provider if you have any side effect that bothers you or that does not go away.

These are not all the possible side effects of Rebif. For more information, ask your healthcare provider or pharmacist.

Call your doctor for medical advice about side effects.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Refer to the Instructions for Use that comes with the Rebif® Rebidose® (interferon beta-1a) autoinjector.

Indication

Rebif is used to treat relapsing forms of MS to decrease the frequency of relapses and delay the occurrence of some of the physical disability that is common in people with MS.