“It’s not about being your own doctor. It’s about being involved in the decision making and asking the right questions.”

Randall Schapiro, MD, FAAN, EMD Serono, Inc employee

One of the first things you may like about Rebif® (interferon beta-1a) is the 3 choices you and your healthcare professional have for how to inject. Rebif® Rebidose® (interferon beta-1a) is a preassembled, prefilled, single-use autoinjector. You can also choose a prefilled syringe with or without the reusable Rebiject II® autoinjector.

Choose your own treatment routine

Finding an MS treatment that fits with your schedule may help make staying with it a little easier. With Rebif, the rule is that you need to take it 3 times a week at least 48 hours apart as prescribed by your doctor. That means you're free to pick the days that work best for you—you can even choose to keep your weekends injection free. For example:

Mon Tues Wed Thurs Fri Sat Sun
    injection-free weekends
Sat injection-free weekends
  • Rebif is injected under the skin.
  • Rebif should be stored refrigerated between 36°F and 46°F (2°C to 8°C). Do not freeze. If a refrigerator is not available, Rebif may be stored between 36°F and 77°F (2°C to 25°C) for up to 30 days and away from heat and light.
  • If you're just starting on Rebif therapy, the Rebif Titration Pack includes preassembled, prefilled dosing. No mixing or measuring required for the 44 mcg dose. Only prefilled syringes can be used to titrate to a 22 mcg prescribed dose.

People may have different experiences with Rebif. For example, you may experience flu-like symptoms or injection-site reactions. If you are experiencing either flu-like symptoms or injection-site reactions, MS LifeLines® can give you tips and information that may help you manage these side effects. The nurses at MS LifeLines are required to be MS certified and are available by calling, toll-free, 1-877-447-3243 Monday through Friday, 8 AM to 10 PM ET, and Saturday and Sunday 9 AM to 5 PM ET.

Please see important safety information below and the Rebif Medication Guide and Prescribing Information at the top of this website, and speak with your healthcare professional for more information. Please see the complete Instructions for Use that comes with your Rebif Rebidose autoinjector.

You have help when and where you need it

MS LifeLines Support 24/7

Over 200 people at MS LifeLines are here to help you start and stay on relapsing MS therapy. Whether you're just thinking about starting Rebif, or you've been on it for some time, MS LifeLines is ready to assist you and your family with questions and concerns. Just call 1-877-447-3243 to reach a live person anytime, 24/7.

MS-certified nurses are great to talk to if you have questions about MS or Rebif. They even make house calls. Or, if you'd like to compare notes with somebody who's been in your shoes, the patient and care partner ambassadors have a lot of personal experience with MS. Be sure to speak with the Financial Support Specialists, too, about what financial assistance programs may be available—whether you have insurance or not.

$0 co-pay (for those eligible)

Call a Financial Support Specialist at 1-877-447-3243 to
learn more.

Call MS LifeLines at 1-877-447-3243
Zero Co-pay for those eligible

You can learn more about all that MS LifeLines offers in
1-on-1 Support.

Attention Patients: Federal and state healthcare program beneficiaries are not eligible for the MS LifeLines® $0 co-pay program. If you participate in a federal or state healthcare program, including Medicare, Medicaid, or any other similar federal or state healthcare program, including any state medical pharmaceutical assistance program, you are not eligible to utilize the MS LifeLines® $0 co-pay program.

Important Safety Information and Indication

Important Safety Information


Before beginning treatment, you should discuss the potential benefits and risks associated with Rebif with your healthcare provider.

Rebif can cause serious side effects. Tell your healthcare provider right away if you have any of the symptoms listed below while taking Rebif.

  • Behavioral health problems, including depression and suicidal thoughts. You may have mood problems including depression (feeling hopeless or feeling bad about yourself), and thoughts of hurting yourself or suicide
  • Liver problems or worsening of liver problems, including liver failure. Symptoms may include nausea, loss of appetite, tiredness, dark colored urine and pale stools, yellowing of your skin or the white part of your eye, bleeding more easily than normal, confusion, and sleepiness. During your treatment with Rebif you will need to see your healthcare provider regularly and have regular blood tests to check for side effects
  • Serious allergic and skin reactions. Symptoms may include itching, swelling of your face, eyes, lips, tongue or throat, trouble breathing, anxiousness, feeling faint, skin rash, hives, sores in your mouth, or skin blisters and peels
  • Injection site problems. Symptoms at the injection site may include redness, pain, swelling, color changes (blue or black), and drainage of fluid
  • Blood problems. Rebif can affect your bone marrow and cause low red and white blood cell and platelet counts. In some people, these blood cell counts may fall to dangerously low levels. If your blood cell counts become very low, you can get infections and problems with bleeding and bruising. Your healthcare provider may ask you to have regular blood tests to check for blood problems
  • Seizures. Some people have had seizures while taking Rebif

Rebif will not cure your MS but may decrease the number of flare-ups of the disease and slow the occurrence of some of the physical disability that is common in people with MS.

Do not take Rebif if you are allergic to interferon beta, human albumin, or any of the ingredients in Rebif.

Before you take Rebif, tell your healthcare provider if you have or have had any of the following conditions:

  • mental illness, including depression and suicidal behavior
  • liver problems, bleeding problems or blood clots, low blood cell counts, seizures (epilepsy), or thyroid problems
  • you drink alcohol
  • you are pregnant or plan to become pregnant. It is not known if Rebif will harm your unborn baby. Tell your healthcare provider if you become pregnant during your treatment with Rebif
  • you are breastfeeding or plan to breastfeed. It is not known if Rebif passes into your breast milk. You and your healthcare provider should decide if you will use Rebif or breastfeed. You should not do both

Tell your healthcare provider about all medicines you take, including prescription and over-the-counter medicines, vitamins and herbal supplements.

The most common side effects of Rebif include:

  • flu-like symptoms. You may have flu-like symptoms when you first start taking Rebif. You may be able to manage these flu-like symptoms by taking over-the-counter pain and fever reducers. For many people, these symptoms lessen or go away over time. Symptoms may include muscle aches, fever, tiredness, and chills
  • stomach pain
  • change in liver blood tests

Tell your healthcare provider if you have any side effect that bothers you or that does not go away.

These are not all the possible side effects of Rebif. For more information, ask your healthcare provider or pharmacist.

Call your doctor for medical advice about side effects.

Refer to the Instructions for Use that comes with Rebif® Rebidose® (interferon beta-1a) autoinjector.


Rebif ® (interferon beta-1a) is used to treat relapsing forms of MS to decrease the frequency of relapses and delay the occurrence of some of the physical disability that is common in people with MS.