“It’s not about being your own doctor. It’s about being involved in the decision making and asking the right questions.”

Randall T Schapiro, MD, FAAN President, The Schapiro MS Advisory Group,
EMD Serono, Inc employee

One of the first things you may like about Rebif® (interferon beta-1a) is the 3 choices you and your healthcare provider have for how to inject. Rebif® Rebidose® (interferon beta-1a) is a preassembled, prefilled, single-use autoinjector. You can also choose a prefilled syringe, with or without the reusable Rebiject II® autoinjector.

Learn about possible side effects

Choose your own Rebif treatment routine

With Rebif, the rule is that you need to take it 3 times a week, at least 48 hours apart, as prescribed by your doctor. That means you have the flexibility to pick the days that work best for you, with this rule in mind. Try to find a routine that fits with your schedule. This may help make staying with Rebif easier. Some people choose a schedule that will keep weekends injection free. For example:

Mon Tues Wed Thurs Fri Sat Sun
Sat injection-free weekends
  • Rebif is injected under the skin.
  • Rebif should be refrigerated between 36°F to 46°F (2°C to 8°C). Do not freeze. If refrigeration is not available, Rebif can be stored between 36°F to 77°F (2°C to 25°C) for up to 30 days, away from heat and light.
  • If you're just starting on Rebif therapy, the Rebif Titration Pack includes premeasured, prefilled dosing. No mixing or measuring required for the 44 mcg dose. Only prefilled syringes can be used to titrate to a 22 mcg prescribed dose.

People may have different experiences with Rebif. For example, you may experience flu-like symptoms or injection-site reactions. If you are experiencing either flu-like symptoms or injection-site reactions, MS LifeLines® can give you tips and information that may help you manage these side effects. The nurses at MS LifeLines are required to be MS certified and are available by calling, toll-free, 1-877-447-3243 Monday through Friday, 8 AM to 10 PM ET and Saturday and Sunday, 9 AM to 5 PM ET.

Please see Important Safety Information below and the Rebif Medication Guide and Prescribing Information at the top of this website, and speak with your healthcare provider for more information. Please see the complete Instructions for Use that comes with your Rebif Rebidose autoinjector.

Learn how to create an MS treatment routine that’s best for you

Our goal is to make sure you feel supported

MS LifeLines Support 24/7

Over 200 people at MS LifeLines are here to help you start and stay on relapsing MS therapy. Whether you're just thinking about starting Rebif, or you've been on it for some time, MS LifeLines is ready to assist you and your family with questions and concerns. Just call 1-877-447-3243 to reach a live person anytime, 24/7.

MS-certified nurses are great to talk to if you have questions about MS or Rebif. Or, if you’d like to compare notes with somebody who’s been in your shoes, the patient and care partner ambassadors have a lot of personal experience with MS. Be sure to speak with the Financial Support Specialists too, about what financial assistance programs may be available—whether you have insurance or not.

Meet the MS LifeLines Nurses
Connect 1-on-1 with a MS LifeLines Ambassador
Talk to a Financial Support Specialist

$0 co-pay* for Rebif if you have insurance. Just call to see if you’re eligible.

Or you can get 1 year of Rebif free if you’re eligible and don’t have insurance or are underinsured. Call a Financial Support Specialist at 1-877-447-3243 to learn more.

Zero Co-pay for those eligible

You can learn more about all that MS LifeLines offers in
1-on-1 Support.

* Or co-insurance.
Some limitations are required by law. Patients covered by federal and state healthcare programs are not eligible for assistance.

Attention Patients: Federal and state healthcare program beneficiaries are not eligible for the $0 co-pay program. If you participate in a federal or state healthcare program, including Medicare, Medicaid, or any other similar federal or state healthcare program, including any state medical pharmaceutical assistance program, you are not eligible to utilize the $0 co-pay program.

Important Safety Information and Indication

Important Safety Information


Before beginning treatment, you should discuss the potential benefits and risks associated with Rebif with your healthcare provider.

Rebif can cause serious side effects. Tell your healthcare provider right away if you have any of the symptoms listed below while taking Rebif.

  • Behavioral health problems, including depression and suicidal thoughts. You may have mood problems including depression (feeling hopeless or feeling bad about yourself), and thoughts of hurting yourself or suicide
  • Liver problems or worsening of liver problems, including liver failure. Symptoms may include nausea, loss of appetite, tiredness, dark colored urine and pale stools, yellowing of your skin or the white part of your eye, bleeding more easily than normal, confusion, and sleepiness. During your treatment with Rebif you will need to see your healthcare provider regularly and have regular blood tests to check for side effects
  • Serious allergic and skin reactions. Symptoms may include itching, swelling of your face, eyes, lips, tongue or throat, trouble breathing, anxiousness, feeling faint, skin rash, hives, sores in your mouth, or skin blisters and peels
  • Injection site problems. Symptoms at the injection site may include redness, pain, swelling, color changes (blue or black), and drainage of fluid
  • Blood problems. Rebif can affect your bone marrow and cause low red and white blood cell and platelet counts. In some people, these blood cell counts may fall to dangerously low levels. If your blood cell counts become very low, you can get infections and problems with bleeding and bruising. Your healthcare provider may ask you to have regular blood tests to check for blood problems
  • Seizures. Some people have had seizures while taking Rebif

Rebif will not cure your MS but may decrease the number of flare-ups of the disease and slow the occurrence of some of the physical disability that is common in people with MS.

Do not take Rebif if you are allergic to interferon beta, human albumin, or any of the ingredients in Rebif.

Before you take Rebif, tell your healthcare provider if you have or have had any of the following conditions:

  • mental illness, including depression and suicidal behavior
  • liver problems, bleeding problems or blood clots, low blood cell counts, seizures (epilepsy), or thyroid problems
  • you drink alcohol
  • you are pregnant or plan to become pregnant. It is not known if Rebif will harm your unborn baby. Tell your healthcare provider if you become pregnant during your treatment with Rebif
  • you are breastfeeding or plan to breastfeed. It is not known if Rebif passes into your breast milk. You and your healthcare provider should decide if you will use Rebif or breastfeed. You should not do both

Tell your healthcare provider about all medicines you take, including prescription and over-the-counter medicines, vitamins and herbal supplements.

The most common side effects of Rebif include:

  • flu-like symptoms. You may have flu-like symptoms when you first start taking Rebif. You may be able to manage these flu-like symptoms by taking over-the-counter pain and fever reducers. For many people, these symptoms lessen or go away over time. Symptoms may include muscle aches, fever, tiredness, and chills
  • stomach pain
  • change in liver blood tests

Tell your healthcare provider if you have any side effect that bothers you or that does not go away.

These are not all the possible side effects of Rebif. For more information, ask your healthcare provider or pharmacist.

Call your doctor for medical advice about side effects.

Refer to the Instructions for Use that comes with Rebif® Rebidose® (interferon beta-1a) autoinjector.


Rebif® (interferon beta-1a) is used to treat relapsing forms of MS to decrease the frequency of relapses and delay the occurrence of some of the physical disability that is common in people with MS.