First, I depend on my internal voice to keep me on track. Then, I analyze where I could be without a therapy and how that could potentially affect me.

“For me, it's all about relaxing during injections, but I do whatever works to keep myself on treatment, and you should find your motivation too.”

Jeanette A. MS LifeLines Ambassador,
living with relapsing MS

Here's some practical, everyday information that everyone taking Rebif® (interferon beta-1a) should become familiar with.

4 tips for taking Rebif

By choosing Rebif, you have taken an important step in treating your relapsing multiple sclerosis. It's important to maintain your treatment regimen as your doctor has prescribed. Here are some tips to consider to help keep you on track:

  • Set remindersOn injection days, set an alarm on your cell phone or another mobile device that can remind you when it's time to inject. Or you can download an app called Mango Health that might help remind you to take Rebif. It may also help you with tips and timely check-ins just for Rebif users. You can learn more about the Mango Health app and download it here.
  • Learn from experiencePut into practice tips that can help with certain side effects. For example, rotating your injection sites may help manage injection-site reactions. You can find more tips on the possible side effects page. For more information, talk to your healthcare provider or call an MS LifeLines Nurse Support Specialist, toll-free, at 1-877-447-3243.
  • Don't go it aloneSometimes, you may feel like taking a break from giving yourself injections—but it's important to stay on your treatment routine! So why not ask a care partner or a nurse for help administering injections, at least for a little while? You may find that this is just the break you were looking for.
  • Feel good about what you're doingIf you're feeling good, connect this feeling to staying on therapy as directed. Try to resist any urges to take a break from therapy because you feel well. Consider rewarding yourself, just for fun—for example, if you put a dollar in a jar each time you inject on schedule, you can treat yourself to something nice after a few months!

Rebif can only work when you take it as prescribed by your doctor.

Please see Important Safety Information below and links to the Rebif Medication Guide and Prescribing Information at the top of this website, and speak with your doctor for more information.

Speak to someone who can tell you more about taking Rebif

5 tips for traveling with Rebif

  • MS LifeLines® provides a free travel kit for anyone taking Rebif. This travel kit includes an insulated container to keep your Rebif cool while you travel. If you do not have a travel kit, call MS LifeLines, toll-free, at 1-877-447-3243 and we will send one to you.

    Remember that you may want to pack a little more medication than you think you'll need in order to cover any travel delays.
  • You should always store your Rebif® Rebidose® (interferon beta-1a) autoinjector in the refrigerator between 36°F and 46°F (2°C to 8°C). Do not freeze. You should check the temperature of the refrigerator you are using while traveling to avoid unintentionally freezing Rebif. For small hotel refrigerators, store Rebif away from the unit's cooling element and small freezer compartment. If a refrigerator is not available, Rebif Rebidose may be stored for up to 30 days between 36°F and 77°F (2°C to 25°C), away from heat and light.
  • If you're traveling by car, don't leave your supplies on the dashboard, in the glove compartment, in the trunk, or in a parked car. Keep your supplies with you in the climate-controlled area of the car. Racks in airplanes (next to the lights) can be too warm as well.
  • If you are flying, keep your supplies with you in your carry-on luggage so they remain with you in case of lost luggage! Prior to flying, be sure to check with your airline and the latest TSA regulations regarding traveling with injectable medicines. These rules are subject to change and may require certain documentation, such as a note from your doctor that describes the medication and why you take it. Go to the Transportation Security Administration website and/or contact your airline for information regarding flying with injectable medications.
  • Remember to bring along an extra ice pack. The Rebif travel kit includes a reusable ice pack.

Rebif can go where you go

However you choose to inject your Rebif, your medicine can travel with you. Request your free Rebif Rebidose travel kit—compliments of MS LifeLines—which can hold up to a 1-month supply.

 Call MS LifeLines at 1-877-447-3243
Rebif travel kit

Get injection reminders with the Mango Health app

Download the free Mango Health app to your mobile device for helpful reminders to take your Rebif injections. You’ll also receive tips and timely check-ins, just for Rebif users. Plus, from MS LifeLines, you’ll get instant access to one-on-one support.

Go to iTunes or Google Play, select Rebif, and you're on your way.

Mango Health is an independent third-party application and is not owned in whole or in part by EMD Serono, Inc. EMD Serono may contribute to sponsored Rebif content provided to users in their Mango Health application user inboxes. Aside from this sponsored Rebif content, EMD Serono does not endorse any of the content contained on Mango Health. Please contact your healthcare provider for specific health or drug information.

Next: Frequently Asked Questions
Important Safety Information and Indication

Important Safety Information


Before beginning treatment, you should discuss the potential benefits and risks associated with Rebif with your healthcare provider.

Rebif can cause serious side effects. Tell your healthcare provider right away if you have any of the symptoms listed below while taking Rebif.

  • Behavioral health problems, including depression and suicidal thoughts. You may have mood problems including depression (feeling hopeless or feeling bad about yourself), and thoughts of hurting yourself or suicide
  • Liver problems or worsening of liver problems, including liver failure. Symptoms may include nausea, loss of appetite, tiredness, dark colored urine and pale stools, yellowing of your skin or the white part of your eye, bleeding more easily than normal, confusion, and sleepiness. During your treatment with Rebif you will need to see your healthcare provider regularly and have regular blood tests to check for side effects
  • Serious allergic and skin reactions. Symptoms may include itching, swelling of your face, eyes, lips, tongue or throat, trouble breathing, anxiousness, feeling faint, skin rash, hives, sores in your mouth, or skin blisters and peels
  • Injection site problems. Symptoms at the injection site may include redness, pain, swelling, color changes (blue or black), and drainage of fluid
  • Blood problems. Rebif can affect your bone marrow and cause low red and white blood cell and platelet counts. In some people, these blood cell counts may fall to dangerously low levels. If your blood cell counts become very low, you can get infections and problems with bleeding and bruising. Your healthcare provider may ask you to have regular blood tests to check for blood problems
  • Seizures. Some people have had seizures while taking Rebif

Rebif will not cure your MS but may decrease the number of flare-ups of the disease and slow the occurrence of some of the physical disability that is common in people with MS.

Do not take Rebif if you are allergic to interferon beta, human albumin, or any of the ingredients in Rebif.

Before you take Rebif, tell your healthcare provider if you have or have had any of the following conditions:

  • mental illness, including depression and suicidal behavior
  • liver problems, bleeding problems or blood clots, low blood cell counts, seizures (epilepsy), or thyroid problems
  • you drink alcohol
  • you are pregnant or plan to become pregnant. It is not known if Rebif will harm your unborn baby. Tell your healthcare provider if you become pregnant during your treatment with Rebif
  • you are breastfeeding or plan to breastfeed. It is not known if Rebif passes into your breast milk. You and your healthcare provider should decide if you will use Rebif or breastfeed. You should not do both

Tell your healthcare provider about all medicines you take, including prescription and over-the-counter medicines, vitamins and herbal supplements.

The most common side effects of Rebif include:

  • flu-like symptoms. You may have flu-like symptoms when you first start taking Rebif. You may be able to manage these flu-like symptoms by taking over-the-counter pain and fever reducers. For many people, these symptoms lessen or go away over time. Symptoms may include muscle aches, fever, tiredness, and chills
  • stomach pain
  • change in liver blood tests

Tell your healthcare provider if you have any side effect that bothers you or that does not go away.

These are not all the possible side effects of Rebif. For more information, ask your healthcare provider or pharmacist.

Call your doctor for medical advice about side effects.

Refer to the Instructions for Use that comes with Rebif® Rebidose® (interferon beta-1a) autoinjector.


Rebif® (interferon beta-1a) is used to treat relapsing forms of MS to decrease the frequency of relapses and delay the occurrence of some of the physical disability that is common in people with MS.