MS Treatment routine
Heidi S. MS LifeLines Ambassador,
living with relapsing MS

When you start on a disease-modifying drug (DMD) to treat relapsing multiple sclerosis (MS), you may be looking for a therapy with product features that allow for flexibility.

Taking Rebif® (interferon beta-1a) 3 times weekly at least 48 hours apart as prescribed by your doctor means that you can pick the days that work best with your schedule—you can even choose to keep your weekends injection free.

Mon Tues Wed Thurs Fri Sat Sun
Sat injection-free weekends

“My typical routine with taking Rebif is Monday, Wednesday, Friday. I like to have my weekend to not have to take a shot. I always make sure that I have a piece of chocolate to treat myself afterward.”

Jennifer O. MS LifeLines Ambassador, living with relapsing MS
Rebif treatment tracking journal

Keeping a treatment journal

When you take Rebif to treat your relapsing MS, it's helpful to keep track of your therapy regimen. Since Rebif is injected 3 times weekly, at least 48 hours apart, it's important to keep track of how you rotate your injection sites. (Refer to the Medication Guide for injection site selection and additional tips.)

MS LifeLines® has developed a downloadable treatment journal that contains information and tips to help you with your Rebif treatment. It also has weekly tracking pages that will let you monitor your injections for a whole year.

Download your treatment journal

Talk to someone who understands living with relapsing MS

If you would prefer to receive a printed version of the treatment journal, just call MS LifeLines at 1-877-447-3243.

By using a planner to monitor your treatment schedule, you can help your healthcare providers get a better understanding of how you are responding to treatment and if you are experiencing any side effects or MS symptoms. If you are experiencing certain side effects, this journal contains tips.

Amy B. RN, MSCN, MS LifeLines Nurse
Next: Practical tips
Important Safety Information and Indication

Important Safety Information


Before beginning treatment, you should discuss the potential benefits and risks associated with Rebif with your healthcare provider.

Rebif can cause serious side effects. Tell your healthcare provider right away if you have any of the symptoms listed below while taking Rebif.

  • Behavioral health problems, including depression and suicidal thoughts. You may have mood problems including depression (feeling hopeless or feeling bad about yourself), and thoughts of hurting yourself or suicide
  • Liver problems or worsening of liver problems, including liver failure. Symptoms may include nausea, loss of appetite, tiredness, dark colored urine and pale stools, yellowing of your skin or the white part of your eye, bleeding more easily than normal, confusion, and sleepiness. During your treatment with Rebif you will need to see your healthcare provider regularly and have regular blood tests to check for side effects
  • Serious allergic and skin reactions. Symptoms may include itching, swelling of your face, eyes, lips, tongue or throat, trouble breathing, anxiousness, feeling faint, skin rash, hives, sores in your mouth, or skin blisters and peels
  • Injection site problems. Symptoms at the injection site may include redness, pain, swelling, color changes (blue or black), and drainage of fluid
  • Blood problems. Rebif can affect your bone marrow and cause low red and white blood cell and platelet counts. In some people, these blood cell counts may fall to dangerously low levels. If your blood cell counts become very low, you can get infections and problems with bleeding and bruising. Your healthcare provider may ask you to have regular blood tests to check for blood problems
  • Seizures. Some people have had seizures while taking Rebif

Rebif will not cure your MS but may decrease the number of flare-ups of the disease and slow the occurrence of some of the physical disability that is common in people with MS.

Do not take Rebif if you are allergic to interferon beta, human albumin, or any of the ingredients in Rebif.

Before you take Rebif, tell your healthcare provider if you have or have had any of the following conditions:

  • mental illness, including depression and suicidal behavior
  • liver problems, bleeding problems or blood clots, low blood cell counts, seizures (epilepsy), or thyroid problems
  • you drink alcohol
  • you are pregnant or plan to become pregnant. It is not known if Rebif will harm your unborn baby. Tell your healthcare provider if you become pregnant during your treatment with Rebif
  • you are breastfeeding or plan to breastfeed. It is not known if Rebif passes into your breast milk. You and your healthcare provider should decide if you will use Rebif or breastfeed. You should not do both

Tell your healthcare provider about all medicines you take, including prescription and over-the-counter medicines, vitamins and herbal supplements.

The most common side effects of Rebif include:

  • flu-like symptoms. You may have flu-like symptoms when you first start taking Rebif. You may be able to manage these flu-like symptoms by taking over-the-counter pain and fever reducers. For many people, these symptoms lessen or go away over time. Symptoms may include muscle aches, fever, tiredness, and chills
  • stomach pain
  • change in liver blood tests

Tell your healthcare provider if you have any side effect that bothers you or that does not go away.

These are not all the possible side effects of Rebif. For more information, ask your healthcare provider or pharmacist.

Call your doctor for medical advice about side effects.

Refer to the Instructions for Use that comes with Rebif® Rebidose® (interferon beta-1a) autoinjector.


Rebif® (interferon beta-1a) is used to treat relapsing forms of MS to decrease the frequency of relapses and delay the occurrence of some of the physical disability that is common in people with MS.