Professional resources


Download, print, or email useful clinician and patient resources about Rebif® and treating relapsing multiple sclerosis (RMS)

Resources for clinicians



Image of the Interferon-β Infographic


Family Planning leaflet

Data on MS relapse rates before, during, and after pregnancy; pregnancy outcomes in interferon-exposed women; and findings on interferon transfer into breast milk.

Image of the Interferon-β Infographic


Pregnancy and Lactation Labeling Rule (PLLR) updates

Summary Rebif® labeling changes based on revised requirements for communicating a prescription drug risks to pregnancy.

Image of the Interferon-β Infographic


Treatment De-escalation leaflet

Safety data, clinical trial results, and general guidance for healthcare professionals when considering switching RMS patients to Rebif®.


EDSS: Expanded Disability Status Scale.

Resources for patients



Image of the Discover Rebif


Patient brochure

Provides information for patients considering treatment with Rebif®.

Image of the Family Planning brochure


Family planning brochure

Provides information about considerations during family planning.

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To request additional materials for patients considering or starting on Rebif®, contact a Rebif® representative.


What a doctor asks new patients

A specialist educates newly diagnosed patients so they can prepare for discussions with healthcare providers.


Managing flu-like symptoms

A neurologist gives patients practical tips to help manage a common side effect of Rebif®.


Injection instruction: prefilled syringe and Rebiject II® Autoinjector

Video teaches patients who have been prescribed Rebif® how to use these two injection devices.






Injection instruction: Rebif® Rebidose® (interferon beta-1a)

Video for patients who will be using the Rebif® Rebidose® injection device.



Important Safety Information

Rebif is contraindicated in patients with a history of hypersensitivity to natural or recombinant interferon beta, human albumin, or any other component of the formulation.

Rebif should be used with caution in patients with depression, a condition that is common in people with multiple sclerosis. Depression, suicidal ideation, and suicide attempts have been reported to occur with increased frequency in patients receiving interferon compounds, including Rebif.

Severe liver injury, including some cases of hepatic failure requiring liver transplantation, has been reported rarely in patients taking Rebif. The potential for liver injury should be considered when used in combination with other products associated with liver injury. Monitor liver function tests and patients for signs and symptoms of hepatic injury. Consider discontinuing Rebif if hepatic injury occurs.

Anaphylaxis and other allergic reactions (some severe) have been reported as a rare complication of Rebif. Discontinue Rebif if anaphylaxis occurs.

In controlled clinical trials, injection site reactions occurred more frequently in Rebif-treated patients than in placebo-treated and Avonex-treated patients. Injection site reactions including injection site pain, erythema, edema, cellulitis, abscess, and necrosis have been reported in the postmarketing setting. Do not administer Rebif into affected area until fully healed; if multiple lesions occur, discontinue Rebif until skin lesions are healed.

Decreased peripheral blood counts in all cell lines, including pancytopenia, have been reported in Rebif-treated patients. In controlled clinical trials, leukopenia occurred at a higher frequency in Rebif-treated patients than in placebo and Avonex-treated patients. Thrombocytopenia and anemia occurred more frequently in 44 mcg Rebif-treated patients than in placebo-treated patients. Patients should be monitored for symptoms or signs of decreased blood counts. Monitoring of complete blood and differential white blood cell counts is also recommended.

Cases of thrombotic microangiopathy (TMA), some fatal, have been reported with interferon beta products, including Rebif, up to several weeks or years after starting therapy. Discontinue Rebif if clinical symptoms and laboratory findings consistent with TMA occur, and manage as clinically indicated.

Caution should be exercised when administering Rebif to patients with pre-existing seizure disorders. Seizures have been temporally associated with the use of beta interferons, including Rebif, in clinical trials and in postmarketing reports.

The most common side effects with Rebif are injection-site disorders, headaches, influenza-like symptoms, abdominal pain, depression, elevated liver enzymes, and hematologic abnormalities.

Epidemiological data do not suggest a clear relationship between interferon beta use and major congenital malformations, but interferon beta may cause fetal harm based on animal studies. Data from a large human population-based cohort study, as well as other published studies over several decades, have not identified a drug-associated risk of major birth defects with interferon beta products during early pregnancy. Findings regarding a potential risk for low birth weight or miscarriage with the use of interferon beta products in pregnancy have been inconsistent.


Rebif is indicated for the treatment of relapsing forms of multiple sclerosis (MS), to include clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease, in adults.

Please see Rebif® Prescribing Information  and Medication Guide.

References: 1. PRISMS Study Group. Randomised double-blind placebo-controlled study of interferon β-1a in relapsing/remitting multiple sclerosis. Lancet. 1998;352(9139):1498-1504. 2. Data on file. EMD Serono, Inc. PRISMS study report. 3. Data on file. EMD Serono, Inc. PRISMS 2010 Confirming analysis. 4. Rebif® [Prescribing Information]. Rockland, MA: EMD Serono, Inc. 5. Freedman MS, Brod S, Wray S, et al. Post hoc Analysis to Evaluate the Effects of Subcutaneous Interferon beta-1a in Subgroups of Patients from the PRISMS Study with Early Onset Versus Late Onset Disease. Poster presented at: ECTRIMS 2019; 11-13 September; Stockholm, Sweden. 6. Li DKB, Paty DW; UBC MS/MRI Analysis Research Group, PRISMS Study Group. Magnetic resonance imaging results of the PRISMS trial: a randomized double-blind, placebo-controlled study of interferon-β1a in relapsing-remitting multiple sclerosis. Ann Neurol. 1999;46(2):197-206.