Do you have questions about getting a COVID-19 vaccine?

If you are on treatment for multiple sclerosis (MS) and have questions about COVID-19 or the COVID-19 vaccines, contact your healthcare provider for answers and guidance. It is very important to continue taking your MS medicine as prescribed and to follow your healthcare provider’s treatment directions.

For additional information, there are helpful online resources that address the question of whether people with MS should get a COVID-19 vaccine, including the National MS Society and the The Consortium of Multiple Sclerosis Centers. To learn more about your vaccination options, talk with your healthcare provider.

US-REB-00324 04/2021


Information, tools, and inspiration to support you on your treatment journey

Whether you’re thinking about starting on Rebif® (interferon beta-1a) or you already take Rebif®, explore this page for helpful downloads, videos, and other information to support you in managing your relapsing multiple sclerosis (RMS).

Resources if you’re thinking about starting on Rebif®




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Rebif® In-office Brochure

Want to learn more about Rebif®? Download our comprehensive guide, which features information on dosing, efficacy, safety, support, and more.

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Choosing your treatment

Gain insights into navigating your treatment options, whether you are newly diagnosed or more experienced in managing RMS.

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Talking to your doctor about RMS

The average neurology appointment only lasts 30-45 minutes, so it’s important to plan ahead. Use this guide to prepare what you want to discuss with your healthcare provider.

What a doctor asks new patients

Hear from a neurologist on what to expect in your first office visits if you have recently been diagnosed with RMS.

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Family planning for people with MS

Get important information about what to consider and what to ask your healthcare provider if you are planning to become pregnant while treating RMS.


Resources if you already take Rebif®



Managing flu-like symptoms

Get helpful tips from a doctor on how to manage flu-like symptoms, a common side effect of some RMS medications.

Injection instruction: prefilled syringe and Rebiject II® autoinjector

Step-by-step guidance on how to inject Rebif® if you use the prefilled syringe or the Rebiject II® autoinjector.

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Injection instruction: Rebif® Rebidose® (interferon beta-1a) autoinjector

Step-by-step guidance if you use the Rebif® Rebidose® device to administer Rebif®.


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Answers to common questions

Have questions about Rebif®? Find answers about treatment as well as about relapsing multiple sclerosis.

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Register to become part of MS LifeLines®

When you register, you’ll get immediate access to our community of financial support specialists and MS-certified nurses, who can assist you in many ways, including by phone, in-home visits, emails, and more to help you stay on track with therapy. 



Important Safety Information

Before beginning treatment, you should discuss the potential benefits and risks associated with Rebif with your healthcare provider.

Rebif can cause serious side effects. Tell your healthcare provider right away if you have any of the symptoms listed below while taking Rebif.

  • Behavioral health problems including depression and suicidal thoughts. You may have mood problems including depression (feeling hopeless or feeling bad about yourself), and thoughts of hurting yourself or suicide
  • Liver problems or worsening of liver problems including liver failure. Symptoms may include nausea, loss of appetite, tiredness, dark colored urine and pale stools, yellowing of your skin or the white part of your eye, bleeding more easily than normal, confusion, and sleepiness. During your treatment with Rebif you will need to see your healthcare provider regularly and have regular blood tests to check for side effects
  • Serious allergic and skin reactions. Symptoms may include itching, swelling of your face, eyes, lips, tongue or throat, trouble breathing, anxiousness, feeling faint, skin rash, hives, sores in your mouth, or skin blisters and peels
  • Injection site problems. Symptoms at the injection site may include redness, pain, swelling, color changes (blue or black), and drainage of fluid
  • Blood problems. Rebif can affect your bone marrow and cause low red and white blood cell and platelet counts. In some people, these blood cell counts may fall to dangerously low levels. If your blood cell counts become very low, you can get infections and problems with bleeding and bruising. Your healthcare provider may ask you to have regular blood tests to check for blood problems
  • Seizures. Some people have had seizures while taking Rebif

Rebif will not cure your MS but may decrease the number of flare-ups of the disease and slow the occurrence of some of the physical disability that is common in people with MS.

Do not take Rebif if you are allergic to interferon beta, human albumin, or any of the ingredients in Rebif.

Before you take Rebif, tell your healthcare provider if you have or have had any of the following conditions:

  • mental illness, including depression and suicidal behavior
  • liver problems, bleeding problems or blood clots, low blood cell counts, seizures (epilepsy), or thyroid problems
  • you drink alcohol
  • you are pregnant or plan to become pregnant. It is not known if Rebif will harm your unborn baby
  • you are breastfeeding or plan to breastfeed. Rebif may pass into your breastmilk. Talk with your healthcare provider about the best way to feed your baby if you take Rebif

Tell your healthcare provider about all medicines you take, including prescription and over-the-counter medicines, vitamins and herbal supplements.

The most common side effects of Rebif include:

  • flu-like symptoms. You may have flu-like symptoms when you first start taking Rebif. You may be able to manage these flu-like symptoms by taking over-the-counter pain and fever reducers. For many people, these symptoms lessen or go away over time. Symptoms may include muscle aches, fever, tiredness, and chills
  • stomach pain
  • change in liver blood tests

Tell your healthcare provider if you have any side effect that bothers you or that does not go away.

These are not all the possible side effects of Rebif. For more information, ask your healthcare provider or pharmacist.

Call your doctor for medical advice about side effects. 

You are encouraged to report negative side effects of prescription drugs to FDA. Visit, or call 1-800-FDA-1088.


Rebif® (interferon beta-1a) is a prescription medicine used to treat relapsing forms of multiple sclerosis, to include clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease, in adults.