Check that the gray needle-cap remover is completely attached to the end of the needle-depth adjuster.
Prepare the injector plunger.
Hold the syringe housing on a flat, hard surface. Align the dark yellow, round end of the device plunger to the gray needle-cap remover. Push the injector body down until it can go no farther and you hear a “click.” The injector plunger is now set. Do not remove the gray needle-cap remover or the syringe plunger.
Note: The Rebiject II® is pre-set to administer an injection 10 mm (3/8 inch) under the skin when the setting reads [>>>]. If your healthcare provider directs you to change the depth setting, follow the instructions in the Maintenance and Troubleshooting Guide section of the Instructions for Use, which is provided with your Rebiject II® autoinjector.
Insert the Rebif® syringe into the syringe housing.
Hold the syringe housing firmly on a flat surface.
Insert the Rebif® syringe, needle-cap end first, into the syringe housing. Be sure to keep the needle-cap on the syringe.
Using gentle pressure, guide the syringe into the syringe housing until 1 to 3 “clicks” are heard.
The syringe is now locked in the housing.
Screw the syringe housing and injector body together.
Pull the needle-cap remover from the syringe housing.
Dispose of the needle-cap, but keep the needle-cap remover for subsequent injections.
Prepare and perform the injection.
Choose your injection site as directed by your healthcare provider. Refer to the Medication Guide for injection site selection and additional tips.
Prepare your injection site as directed by your healthcare provider.
Place the Rebiject II® lightly against your skin so that you can see the indicator window.
Apply light pressure so that the injector body moves downward toward the syringe housing. This releases the safety lock so that the release button can be pressed.
Inject Rebif® medication.
Press the injector release button and continue to hold the Rebiject II® in place on your skin for at least 10 seconds. The contents will be automatically injected.
Check the indicator window.
You will see a series of black lines moving against a yellow background. Once the injection is complete, the lines will stop moving.
Lift the Rebiject II® from the skin and apply gentle pressure to the injection site with a dry cotton ball or sterile gauze.
Applying a cold compress or ice pack to the injection site after injection may help reduce local skin reactions.
Disassemble the Rebiject II®.
Unscrew the syringe housing from the injector body.
The syringe needle will now be exposed. Be careful when handling.
Remove the syringe from the syringe housing.
Dispose of the empty needle and syringe properly in the syringe disposal container.*
Reattach the needle-cap remover and the needle-depth adjuster, and store the Rebiject II® in its case. Remember to clean your Rebiject II® prior to storing. The Rebiject II® may be cleaned by wiping with a damp cloth if needed. Do not use soap or place in boiling water, a microwave, or an autoclave.
Keep a record of the date and injection site in your treatment journal.
Check recent injection sites for redness, swelling, or tenderness. Contact your healthcare provider about any skin reaction that does not clear up in a few days. You can also contact an MS LifeLines® Nurse Support Specialist, who can give you tips that may help manage these reactions.
*Regulations for disposal vary. Consult your healthcare provider or pharmacist for regulations in your area.
If you need help
Contact your doctor, nurse, or other healthcare professional, or call MS LifeLines® toll-free at 1-877-447-3243, Monday through Friday, 8 AM to 8 PM ET, and Saturday, 9 AM to 5 PM ET, if:
You are unsure about any of these steps
The Rebiject II® prefilled autoinjector is not working properly
You cannot perform the injection using the Rebiject II®
A live representative answers every call, day or night.
Every effort has been made to ensure that the Rebiject II® will function correctly for at least 2 years. After 2 years of operation, your Rebiject II® should be replaced. A new Rebiject II® can be obtained by calling MS LifeLines®, toll-free, at 1-877-447-3243.
Warnings and safety precautions
Do not inject yourself using the Rebiject II® autoinjector until you have been properly trained by a doctor, nurse, or other healthcare provider.
The Rebiject II® autoinjector must only be used with your prescribed prefilled glass syringes of Rebif® and should not be used with any other brand of interferon or medication.
Do not share the Rebiject II® autoinjector with anyone. Doing so may result in injury and/or the transmission of infectious blood-borne diseases. Adhere to strict safety and antiseptic precautions at all times.
Always keep the Rebiject II® autoinjector and Rebif® out of the reach of children.
Do not operate or store the Rebiject II® autoinjector with an empty syringe.
Do not point the Rebiject II® autoinjector at yourself or others when loading the syringe or at any other time.
For more information about the Rebiject II® autoinjector, call MS LifeLines®, toll-free, at 1-877-447-3243. For complete instructions on the use of the Rebiject II® autoinjector, please refer to the instructions that came with it.