Practical tips for people taking Rebif® (interferon beta-1a)

Here’s some practical, everyday information that everyone taking Rebif® should become familiar with. While incorporating these tips into your daily routine, it’s important to remember to keep taking treatment as prescribed by your healthcare provider.


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5 tips for taking Rebif®

  1. Set reminders
    On injection days, set an alarm on your cell phone or other mobile devices that can remind you when it’s time to inject. There are also many apps available that may help you remember.

  2. Don't go it alone
    Giving yourself injections takes some getting used to. Over time and with practice, you may feel more confident. You can ask your MS LifeLines® Nurse to teach a friend or family member about injection techniques so they can assist you.

  3. Find your happy place
    It may help to think about something relaxing before you inject. Breathing slowly, listening to music or soothing sounds, or imagining your favorite place can put you in the right state of mind.

  4. Schedule a refresher
    If you’ve been injecting for a while, it’s sometimes helpful to brush up on your injection technique. Set up some time with your MS LifeLines® Nurse, who may be able to give you some new tips.

  5. Feel good about what you’re doing
    Know that you’re doing what you can to help manage relapsing multiple sclerosis (RMS). Consider rewarding yourself, just for fun—for example, if you put a dollar in a jar each time you inject on schedule, you can treat yourself to something nice after a few months!


Please see Important Safety Information below, the Rebif® Medication Guide and Prescribing Information, and speak with your healthcare provider for more information.

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5 tips for traveling with Rebif®

  1. MS LifeLines® provides a free travel kit for anyone taking Rebif®. This travel kit includes an insulated container to keep your Rebif® cool while you travel. If you do not have a travel kit, call MS LifeLines® toll-free at 1-877-447-3243, and we will send one to you.

    Remember that you may want to pack a little more medication than you think you’ll need in order to cover any travel delays.

  2. You should always store your Rebif® in the refrigerator between 36 °F and 46 °F (2 °C and 8 °C). Do not freeze. You should check the temperature of the refrigerator that you are using while traveling to avoid unintentionally freezing Rebif®. For small hotel refrigerators, store Rebif® away from the unit's cooling element and small freezer compartment. If a refrigerator is not available, Rebif® may be stored for up to 30 days between 36 °F and 77 °F (2 °C and 25 °C), away from heat and light.

  3. If you're traveling by car, don't leave your supplies on the dashboard, in the glove compartment, in the trunk, or in a parked car. Keep your supplies with you in the climate-controlled area of the car.

  4. If you are flying, keep your supplies with you in your carry-on bag so that they remain with you in case of lost luggage! It is safe to pass Rebif® and Rebif® Rebidose® through screening devices. Don’t keep Rebif® in the overhead rack—the lights can make the storage space too warm.

    Prior to flying, be sure to check with your airline and the latest TSA regulations regarding traveling with injectable medicines. These rules are subject to change and may require certain documentation, such as a note from your healthcare provider that describes the medication and why you take it. You can also print a card from the TSA website that identifies you as someone with MS. This card may help expedite things at the TSA screening checkpoint. Go to, click on “Disabilities and Medical Conditions,” and follow instructions for the “TSA Notification Card."

  5. Remember to bring along an empty biohazard (sharps) container and an extra ice pack. The Rebif® Travel Kit includes a reusable ice pack.



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Get your free travel kit!

However you choose to inject your Rebif®, your medicine can travel with you. Request your free Rebif® Rebidose® Travel Kit — compliments of MS LifeLines® — which can hold up to a 1-month supply. 

Call MS LifeLines® at 1-877-447-3243.


Important Safety Information

Do not take Rebif if you are allergic to interferon beta, human albumin, or any of the ingredients in Rebif.

Rebif can cause serious side effects. Tell your healthcare provider right away if you have any of the symptoms listed below while taking Rebif.

  • Behavioral health problems including depression and suicidal thoughts. You may have mood problems including depression (feeling hopeless or feeling bad about yourself), and thoughts of hurting yourself or suicide.
  • Liver problems or worsening of liver problems including liver failure. Symptoms may include nausea, loss of appetite, tiredness, dark colored urine and pale stools, yellowing of your skin or the white part of your eye, bleeding more easily than normal, confusion, and sleepiness. During your treatment with Rebif you will need to see your healthcare provider regularly and have regular blood tests to check for side effects.
  • Serious allergic and skin reactions. Symptoms may include itching, swelling of your face, eyes, lips, tongue or throat, trouble breathing, anxiousness, feeling faint, skin rash, hives, sores in your mouth, or skin blisters and peels.
  • Injection site problems. Rebif may cause redness, pain, itching or swelling at the place where your injection was given. Call your healthcare provider right away if an injection site becomes swollen and painful or the area looks infected. You may have a skin infection or an area of severe skin damage (necrosis) requiring treatment by a healthcare provider.
  • Blood problems. Rebif can affect your bone marrow and cause low red and white blood cell and platelet counts. In some people, these blood cell counts may fall to dangerously low levels. If your blood cell counts become very low, you can get infections and problems with bleeding and bruising. Your healthcare provider may ask you to have regular blood tests to check for blood problems.
  • Seizures. Some people have had seizures while taking Rebif.

Before you take Rebif, tell your healthcare provider if you have or have had any of the following conditions:

  • mental illness, including depression and suicidal behavior
  • liver problems
  • bleeding problems or blood clots
  • low blood cell counts
  • seizures (epilepsy)
  • thyroid problems
  • you drink alcohol
  • you are pregnant or plan to become pregnant. It is not known if Rebif will harm your unborn baby. Tell your healthcare provider if you become pregnant during your treatment with Rebif
  • you are breastfeeding or plan to breastfeed. It is not known if Rebif passes into your breast milk. You and your healthcare provider should decide if you will use Rebif or breastfeed. You should not do both

Tell your healthcare provider about all medicines you take, including prescription and over-the-counter medicines, vitamins and herbal supplements.

The most common side effects of Rebif include:

  • flu-like symptoms. You may have flu-like symptoms when you first start taking Rebif. You may be able to manage these flu-like symptoms by taking over-the-counter pain and fever reducers. For many people, these symptoms lessen or go away over time. Symptoms may include muscle aches, fever, tiredness, and chills
  • stomach pain
  • change in liver blood tests

Tell your healthcare provider if you have any side effect that bothers you or that does not go away.

These are not all the possible side effects of Rebif. For more information, ask your healthcare provider or pharmacist.

Call your doctor for medical advice about side effects.

You are encouraged to report negative side effects of prescription drugs to FDA.
Visit, or call 1-800-FDA-1088.


Rebif® (interferon beta-1a) is a prescription medicine used to treat relapsing forms of multiple sclerosis, to include clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease, in adults. It is not known if Rebif is safe and effective in children.

Please see Rebif® Prescribing Information and Medication Guide.