WHY REBIF® (interferon beta-1a)

Navigating and treating RMS

Whether you’re newly diagnosed or more experienced in managing relapsing multiple sclerosis (RMS), living with the disease can be unpredictable. Starting or staying with a treatment is an important decision, and that’s why it is crucial to research different treatment options. When you and your healthcare provider are discussing what you want out of your treatment, you may want to keep these 3 important goals in mind:

Reduce Rate of Flare-ups

Slow Disability Progression

Reduce Number of New or Enlarging Brain Lesions

All RMS treatments have an effect on the immune system, your body’s natural defense system against harmful substances such as viruses, fungi, bacteria, toxins, and foreign particles. Although treatment may help reduce the frequency of relapses, it could also make you more vulnerable to many of the illnesses or medical challenges from which your immune system usually protects you. That’s why considering both safety and efficacy is important. Work with your healthcare provider to find an RMS treatment option that is right for you.



Reasons to consider Rebif® for your RMS


Rebif® has proven results

Clinicial trials proved Rebif® effective in treating RMS in important ways compared to placebo, including fewer flare-ups. And Rebif® was proven superior to Avonex®, another interferon beta-1a RMS treatment, in a head-to-head study.

Rebif® has a well-established safety profile

Through 20+ years of combined clinical trial data and real-world patient experience, Rebif® has a well-established safety profile and has been prescribed to more than 145,000 patients in the US since 2002.

Rebif® offers options

Rebif® gives you the choice of 3 injection devices and the ability to choose 3 dosing days, 48 hours apart, that work best for you.

Rebif® gives you support

If you take Rebif®, you have free access to caring experts—including Financial Specialists for guidance on insurance coverage and MS-certified nurses for questions about treatment.

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Choosing your treatment

Gain insights into navigating your treatment options, whether you are newly diagnosed or more experienced in managing RMS.

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Family planning when you have RMS

See data to learn about considerations for family planning while taking Rebif®


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Get $0 co-pay* info

See if you may be able to receive Rebif® at no cost to you. 

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Order free information kit

Want more information about Rebif®? Get our free kit. 


*People with insurance or co-insurance may be eligible.
Attention Patients: Federal and state healthcare program beneficiaries are not eligible for the MS LifeLines® $0 co-pay program. If you participate in a federal or state healthcare program, including Medicare, Medicaid, TRICARE, the Department of Veterans Affairs, the Department of Defense, or any other similar federal or state healthcare program, including any state medical pharmaceutical assistance program, you are not eligible to utilize the MS LifeLines® $0 co-pay program.



Important Safety Information

Do not take Rebif if you are allergic to interferon beta, human albumin, or any of the ingredients in Rebif.

Rebif can cause serious side effects. Tell your healthcare provider right away if you have any of the symptoms listed below while taking Rebif.

  • Behavioral health problems including depression and suicidal thoughts. You may have mood problems including depression (feeling hopeless or feeling bad about yourself), and thoughts of hurting yourself or suicide.
  • Liver problems or worsening of liver problems including liver failure. Symptoms may include nausea, loss of appetite, tiredness, dark colored urine and pale stools, yellowing of your skin or the white part of your eye, bleeding more easily than normal, confusion, and sleepiness. During your treatment with Rebif you will need to see your healthcare provider regularly and have regular blood tests to check for side effects.
  • Serious allergic and skin reactions. Symptoms may include itching, swelling of your face, eyes, lips, tongue or throat, trouble breathing, anxiousness, feeling faint, skin rash, hives, sores in your mouth, or skin blisters and peels.
  • Injection site problems. Rebif may cause redness, pain, itching or swelling at the place where your injection was given. Call your healthcare provider right away if an injection site becomes swollen and painful or the area looks infected. You may have a skin infection or an area of severe skin damage (necrosis) requiring treatment by a healthcare provider.
  • Blood problems. Rebif can affect your bone marrow and cause low red and white blood cell and platelet counts. In some people, these blood cell counts may fall to dangerously low levels. If your blood cell counts become very low, you can get infections and problems with bleeding and bruising. Your healthcare provider may ask you to have regular blood tests to check for blood problems.
  • Pulmonary arterial hypertension. Pulmonary arterial hypertension can occur with interferon beta products, including Rebif. Symptoms may include new or increasing fatigue or shortness of breath. Contact your healthcare provider right away if you develop these symptoms.
  • Seizures. Some people have had seizures while taking Rebif.

Before you take Rebif, tell your healthcare provider if you have or have had any of the following conditions:

  • mental illness, including depression and suicidal behavior
  • liver problems
  • bleeding problems or blood clots
  • low blood cell counts
  • seizures (epilepsy)
  • thyroid problems
  • drink alcohol
  • are pregnant or plan to become pregnant. It is not known if Rebif will harm your unborn baby. Tell your healthcare provider if you become pregnant during your treatment with Rebif
  • are breastfeeding or plan to breastfeed. Rebif may pass into your breastmilk. Talk with your healthcare provider about the best way to feed your baby if you take Rebif.

Tell your healthcare provider about all medicines you take, including prescription and over-the-counter medicines, vitamins and herbal supplements.

The most common side effects of Rebif include:

  • flu-like symptoms. You may have flu-like symptoms when you first start taking Rebif. You may be able to manage these flu-like symptoms by taking over-the-counter pain and fever reducers. For many people, these symptoms lessen or go away over time. Symptoms may include muscle aches, fever, tiredness, and chills
  • stomach pain
  • change in liver blood tests

Tell your healthcare provider if you have any side effect that bothers you or that does not go away.

These are not all the possible side effects of Rebif. For more information, ask your healthcare provider or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or visit  www.fda.gov/medwatch.


Rebif® (interferon beta-1a) is a prescription medicine used to treat relapsing forms of multiple sclerosis, to include clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease, in adults. It is not known if Rebif is safe and effective in children.

Please see Rebif® Prescribing Information and Medication Guide.